Phytochemical constituents and biological activities of active fractions from Silene conoidea root

Taleghani, Akram; Eghbali, Samira; Moghimi, Roya

doi:10.22051/jab.2025.46988.1624

Document Type : Research Paper

Authors

¹ Department of Chemistry, Faculty of Science, Gonbad Kavous University, Gonbad, Iran

² Department of Pharmacognosy, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran

³ Assistant Professor, Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

https://doi.org/10.22051/jab.2025.46988.1624

Abstract

Introduction: Silene conoidea (family: Caryophyllaceae) as an rarely distributed edible weed in Iran, have a medicinal properties such as insecticidal, antimicrobial, antibacterial and allelopathic effect. Material & Methods: This is the first report to investigate the phytochemical contents, phytochemical compounds and biological activities of six successive fractions (petroleum ether, chloroform, dichloromethane, ethyl acetate, methanol and water) obtained from root of species for natural new drug development. Results & discussion: The methanol fraction of root exhibited a strong antioxidant activity than the BHT (IC50: 11.61± 1.34 µg/ml). Also, chloroform and methanol fractions revealed moderate antimicrobial activity against bacterial strains with MIC values in range of 0.0625 to 0.25 mg/ml compared to gentamicin. The more active fractions (chloroform and methanol) were processed for bioactive compounds identification. Forty compounds representing 97.98 % of the total composition were detected by GC-MS from the chloroform fraction of root. The main constituents were dominated by fatty acid derivatives (63.98%), hydrocarbons (20.58%) and terpene derivatives (6.82%). The LC-ESI-MS study of methanol fraction reveals the presence of common composition groups, including flavonoids, steroids and triterpenoid saponins. Apigenin, diosmin, swertisin-2′′-O-glucoside and hesperetin were identified as bioactive compounds. Conclusion: The results of this study showed that S. conoidea root can be used in pharmaceutical and food industries.

Keywords

Main Subjects

Herbal

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Applied Biology

Phytochemical constituents and biological activities of active fractions from Silene conoidea root

References

References

Volume 38, Issue 1 - Serial Number 83
February 2025
Pages 61-72

Phytochemical constituents and biological activities of active fractions from Silene conoidea root

References

References

Volume 38, Issue 1 - Serial Number 83February 2025Pages 61-72

Volume 38, Issue 1 - Serial Number 83
February 2025
Pages 61-72