Neuroprotective effects of alpha-pinene nanophytosome on oxidative damage induced by carbon tetrachloride (CCl4)

Hajizadeh Moghaddam, Akbar; Taghizadeh, Kosar; Khanjani Jelodar, Sedigheh; Hasantabar, Vahid

doi:10.22051/jab.2023.43921.1578

Document Type : Research Paper

Authors

¹ Associate Professor.Department of Animal Sciences, Faculty of Basic Sciences, Mazandaran University, Babolsar, Mazandaran, Iran

² MSc student, Department of Animal Sciences, Faculty of Basic Sciences, Mazandaran University, Babolsar, Mazandaran, Iran

³ Assistant Professor.Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol,

⁴ Graduated, Department of Polymer Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Mazandaran, Iran

10.22051/jab.2023.43921.1578

Abstract

Introduction: Carbon tetrachloride (CCl4) is a common chemical solvent that causes oxidative stress and brain damage. Alpha-pinene with antioxidant properties plays an important role in reducing oxidative stress and improving inflammation. However, Alpha-pinene has low bioavailability due to low solubility. The purpose of this study is to investigate the protective effects of Alpha-pinene nanophytosome on brain damage caused by CCl4 in male rats. Metods: In this research, 35 male Wistar rats were divided into five groups control, Alpha-pinene nanophytosome (50 mg/kg ) for 14 days, CCl4 (1 mg/kg) twice a week for 14 days and two CCl4 treated groups with Alpha-pinene and Alpha-pinene nanophytosome (50 mg/kg ) for 14 days. Finally, the levels of malondialdehyde (MDA) and glutathione (GSH) as well as the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzymes were investigated. Results and discussion: Our results revealed that, the level of GSH (P<0.001) and the activity of antioxidant enzymes (P<0.01) in the brain of rats receiving CCl4 significantly decreased compared to the control group, while Alpha-pinene nanophytosome increased significantly. The level of MDA in the brain of rats receiving CCl4 increased significantly (P<0.001) compared to the control group, while Alphapinene nanophytosome significantly reduced MDA level. The findings of this research show that Alpha-pinene nanophytosome can protects the brain against oxidative stress and damage caused by CCl4.

Keywords

Main Subjects

animal

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Applied Biology

Neuroprotective effects of alpha-pinene nanophytosome on oxidative damage induced by carbon tetrachloride (CCl4)

References

References

Volume 36, Issue 4 - Serial Number 78
March 2024
Pages 38-46

Neuroprotective effects of alpha-pinene nanophytosome on oxidative damage induced by carbon tetrachloride (CCl4)

References

References

Volume 36, Issue 4 - Serial Number 78March 2024Pages 38-46

Volume 36, Issue 4 - Serial Number 78
March 2024
Pages 38-46