Herbal
Akram Taleghani; Samira Eghbali; Roya Moghimi
Abstract
Introduction: Silene conoidea (family: Caryophyllaceae) as an rarely distributed edible weed in Iran, have a medicinal properties such as insecticidal, antimicrobial, antibacterial and allelopathic effect. Material & Methods: This is the first report to investigate the phytochemical contents, phytochemical ...
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Introduction: Silene conoidea (family: Caryophyllaceae) as an rarely distributed edible weed in Iran, have a medicinal properties such as insecticidal, antimicrobial, antibacterial and allelopathic effect. Material & Methods: This is the first report to investigate the phytochemical contents, phytochemical compounds and biological activities of six successive fractions (petroleum ether, chloroform, dichloromethane, ethyl acetate, methanol and water) obtained from root of species for natural new drug development. Results & discussion: The methanol fraction of root exhibited a strong antioxidant activity than the BHT (IC50: 11.61± 1.34 µg/ml). Also, chloroform and methanol fractions revealed moderate antimicrobial activity against bacterial strains with MIC values in range of 0.0625 to 0.25 mg/ml compared to gentamicin. The more active fractions (chloroform and methanol) were processed for bioactive compounds identification. Forty compounds representing 97.98 % of the total composition were detected by GC-MS from the chloroform fraction of root. The main constituents were dominated by fatty acid derivatives (63.98%), hydrocarbons (20.58%) and terpene derivatives (6.82%). The LC-ESI-MS study of methanol fraction reveals the presence of common composition groups, including flavonoids, steroids and triterpenoid saponins. Apigenin, diosmin, swertisin-2′′-O-glucoside and hesperetin were identified as bioactive compounds. Conclusion: The results of this study showed that S. conoidea root can be used in pharmaceutical and food industries.
