azam makipour; ashraf jazayeri; esmaeil darabpour
Abstract
Nowadays, emergence and prevalence of drug-resistant pathogenic bacteria has become a great global concern. So, there is an urgent need to discover new antimicrobial agents. The mucus of mudskipper fish may be a new, untapped source for antibacterial agents. The aim of this study was to evaluate the ...
Read More
Nowadays, emergence and prevalence of drug-resistant pathogenic bacteria has become a great global concern. So, there is an urgent need to discover new antimicrobial agents. The mucus of mudskipper fish may be a new, untapped source for antibacterial agents. The aim of this study was to evaluate the antibacterial activity of the mucus of Periophthalmus waltoni, isolated from Musa estuary, against four pathogenic bacteria, including Escherichia coli, Bacillus subtillis, Pseudomonas aeruginosa and Staphylococcus aureus. The effect of gender and seasonal variations on antibacterial activity of mucus was also evaluated. After preparation of the aqueous mucus extract, the antibacterial activity was assessed using disc diffusion method. Also, the minimal Inhibitory Concentration (MIC) and minimum bactericidal concentration (MBC) of the mucus extract was determined against two more sensitive bacteria.The results revealed that tested bacteria were susceptible to the mucus extract. Bacillus subtillis and Pseudomonas aeruginosa were the most susceptible and resistant bacteria to the mucus extract, respectively. The gender of the fish did not make a significant difference in the antimicrobial activity of mucus, However, female fish showed slightly higher antimicrobial activity (P>0/001). It was also found that fish’s mucus has the higher antibacterial property in the spring season (P<0/001).
