تاثیرات عصاره آبی-اتانولی برگهای گیاه بابا آدم بر ترمیم زخم

نوع مقاله: مقاله پژوهشی

نویسنده

استادیار گروه زیست شناسی، دانشکده علوم پایه، دانشگاه بوعلی سینا همدان

چکیده

ترمیم زخم فرآیند پیچیده­ای هست و مطالعات نشان داده است که شمار زیادی از تولیدات طبیعی همچون داروهای گیاهی تاثیرات مهمی در تنظیم فرایند ترمیم زخم دارند. مطالعات فارماکولوژیکی نشان داده است که گیاه بابا آدم دارای فعالیت ضد­التهابی، ضد­میکروبی و ضد تکثیری می­باشند هدف از این مطالعه بررسی تاثیرات عصاره گیاه بابا آدم بر فرآیند ترمیم زخم می­باشد. مدل زخم برشی در رَت نژاد ویستار ایجاد شد. حیوانات به سه گروه 6 تایی: کنترل ، حامل و گروه تیمار  تقسیم شدند. اندازه زخم، تعداد سلولهای التهابی، انباشت رشته­های کلاژن و وسعت بافت التیامی ارزیابی شد. تعداد سلولهای التهابی از لحاظ آماری به روش one-way ANOVA، به همراه تستTukey’s Post hocبررسی شدند. نتایج نشان دادند که تعداد سلولهای التهابی به طور معنی­داری در گروه تیمار نسبت به گروههای کنترل وحامل کاهش پیدا کرد. همچنین نتایج نشان داد که وسعت بافت التیامی در گروه تیمار کاهش یافت و میزان انباشت رشته­های کلاژن در گروه تیمار به شکل معنی داری نسبت به گروه کنترل و حامل افزایش یافت. مطالعه ما نشان داد که عصاره آبی-اتانولی گیاه بابا­آدم تاثیرات مفیدی در بهبود مدل زخمهای برشی دارد.

کلیدواژه‌ها

عنوان مقاله [English]

The effects of hydro-ethanolic extract of Arctium lappa leaves on wound healing

نویسنده [English]

  • Siamak Yari

Asistant professor Bu-Ali Sina University, Faculty of Science, Department of Biology

چکیده [English]

Wound healing is a complex process and studies show that many natural products such as herbal drugs have important effects on modulating of this process. Pharmacological studies indicated that Arctium lappa have anti-inflammatory, antimicrobial and anti-proliferative activities. The aim of this study was to evaluate the effects of Arctium lappa extract on wound healing process. Excision wound model was created in Wistar rats. The animals divided into three groups (n=6): control, vehicle and treatment group. Wound size, Number of inflammatory cells, collagen deposition and scar tissue area were studied. Number of inflammatory cells, statically were analyzed by one-way ANOVA followed by the Tukey’s post hoc test. Results show that number of inflammatory cells were significantly decreased in treated group compared to control and vehicle groups. Scar tissue reduced in treated groups and collagen deposition significantly increased in extract treated groups. Our study demonstrates that Arctium lappa have beneficial effects on healing of excision wound model. 

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